Micky van de Ven Brace Ends The Toffees' Run at New Stadium
Micky van de Ven became the initial backline player to net two goals in a Premier League match for Tottenham since Jan Vertonghen in March 2013.
Match summary
Micky Van de Ven heads into the net two times in first half
Everton's Jake O'Brien has goal disallowed after VAR review
Pape Matar Sarr scores final goal in 89th minute
The defeat is Everton's initial at their new ground
Micky van de Ven found the net twice as Spurs prolonged their unbeaten run on the road in the top division and delivered the Toffees their initial loss at their new home.
The Toffees were undefeated in their five previous fixtures at their new ground at the dockside location, having left Goodison Park behind after more than a century at the conclusion of the previous campaign.
But Tottenham's leader Van de Ven struck twice from set-pieces in the first half to place their strong form at risk, and they were failed to turn it around before Pape Matar Sarr - assisted by former Toffees attacker Richarlison - headed home a final goal to put the game to bed.
Jake O'Brien believed he had levelled the scores five minutes after the defender's opener, glancing a powerful header past the Spurs keeper from an Everton corner.
The Portuguese striker, in the meantime, missed a number of chances, while the Italian goalkeeper made a succession of excellent stops to ensure the London club went five matches on the road without defeat in the Premier League.
But the VAR stepped in, advising the match official to check the goal on the pitchside monitor and the referee ruled that the winger and the attacker were in an illegal position and had interfered with the Tottenham goalkeeper.
The win elevates the manager's team into third place in the division, a handful of points off local foes and leaders Arsenal.
The Merseyside club remain 14th and sit six points clear of the relegation zone.
Tottenham analysis: The defender excels in duties at each end of pitch
Following a drab midweek display in the European competition against the French side, where they mustered a only two shots on target, Frank chose Randal Kolo Muani up front instead of former Toffees player the Brazilian.
The summer signing was unable to influence the game before being substituted for Richarlison after an hour on the field, but it emerged he wasn't needed in the end.
Centre-back the Dutchman converted into an offensive threat to be feared.
Tottenham's opening strike came from a well-worked set-piece play, with Rodrigo Bentancur directing the ball back across the six-yard box for an free the defender to head home.
And Ven de Ven - filling in as skipper in Cristian Romero's unavailability - notched his second in first-half stoppage time as he outjumped the England keeper to head home.
The Dutchman was just as impressive in defensive duties, partnering effectively with his defensive colleague as the pair dealt excellently with the numerous deliveries thrown their way by Everton.
Everton analysis: Everton missing striker's instinct
The club's new home had been a fortress, but it appears the novelty may have faded slightly and supporters headed to the gates after Sarr's third for Tottenham.
The break in the team's winning streak at home won't be a major concern for the manager, but their striker situation will be.
Beto and Thierno Barry - the Everton's two recognised centre-forwards - had netted just one league goal between them before the weekend's match.
And they were unable to contribute to that miserable record on a damp and dreary evening on Merseyside.
Beto's form was summed up when he opted to overhead kick a golden opportunity from near the goal, even with having space and opportunity to reposition for a more conventional shot that would have tested the keeper.
The substitute, as well, failed to influence the game after coming on for Beto in the second half.
It wasn't for a lack of chance. Most of Everton's offensive moves came through Grealish and the forward, who tirelessly delivered dangerous crosses into the Tottenham box.
What next for both teams?
Everton: The team head to Sunderland in the Premier League on Monday, 3 November at 8 PM.
Tottenham: The London club go to Newcastle's ground on Wednesday, 29 October for their next round Carabao Cup tie against Newcastle.